Hydroxylamine → HCID 86607869, compound

HRID 736717Notes

Reaction equation

[CH3:1][N:2]([S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[C:25]([CH3:33])[CH:24]=2)=[CH:17][CH:16]=1)(=[O:14])=[O:13])[C@@H:3]1[C@H:8]([C:9](O)=[O:10])[CH2:7][CH:6]=[CH:5][CH2:4]1.[NH2:34][OH:35]>>[OH:35][NH:34][C:9]([C@H:8]1[C@@H:3]([N:2]([CH3:1])[S:12]([C:15]2[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]3[C:32]4[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=4)[N:26]=[C:25]([CH3:33])[CH:24]=3)=[CH:19][CH:20]=2)(=[O:14])=[O:13])[CH2:4][CH:5]=[CH:6][CH2:7]1)=[O:10]

Participants

Reactant 2

HCID 787Hydroxylamine

HCID 68819518HCID 68819518, compound

Product 1

HCID 86607869HCID 86607869, compoundYield 94%

Procedure

According to the procedure of Example 10, Step 2, the reaction of 255.5 mg (0.4 mmol) of cis-6-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohex-3-ene-1-carboxylic acid with hydroxylamine provided 200.1 mg of cis-N-hydroxy-6-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohex-3-ene-1-carboxamide in 94% yield. MS: 482.1 (M+H)+

Sources & evidence

ORD record: ord-25b0c0045c6a4f96a25b410e3ef7aeaf
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

Loading…