Trifluoroacetic acid → HCID 68820136, compound

HRID 736719Notes

Reaction equation

[CH3:1][N:2]([S:15]([C:18]1[CH:23]=[CH:22][C:21]([O:24][CH2:25][C:26]2[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[N:29]=[C:28]([CH3:36])[CH:27]=2)=[CH:20][CH:19]=1)(=[O:17])=[O:16])[C@H:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([O:10]C(C)(C)C)=[O:9].FC(F)(F)C(O)=O>>[CH3:1][N:2]([S:15]([C:18]1[CH:19]=[CH:20][C:21]([O:24][CH2:25][C:26]2[C:35]3[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=3)[N:29]=[C:28]([CH3:36])[CH:27]=2)=[CH:22][CH:23]=1)(=[O:17])=[O:16])[C@H:3]1[CH2:7][CH2:6][CH2:5][C@H:4]1[C:8]([OH:10])=[O:9]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 68821202HCID 68821202, compound

Product 1

HCID 68820136HCID 68820136, compound

Procedure

According to the procedure of Example 15, Step 3, the reaction of 215 mg (0.42 mmol) of tert-butyl cis-2-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylate with trifluoroacetic acid provided cis-2-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclopentanecarboxylic acid in quantitative yield. MS: 455.1 (M+H)+

Sources & evidence

ORD record: ord-9a5d625ef8b242f1b6aa253522b999f0
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

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