Trifluoroacetic acid → HCID 68818828, compound

HRID 736727Notes

Reaction equation

[C:1]([N:4]1[CH2:8][C@H:7]([NH:9][S:10]([C:13]2[CH:18]=[CH:17][C:16]([O:19][CH2:20][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[N:24]=[C:23]([CH3:31])[CH:22]=3)=[CH:15][CH:14]=2)(=[O:12])=[O:11])[C@H:6]([C:32]([O:34]C(C)(C)C)=[O:33])[CH2:5]1)(=[O:3])[CH3:2].FC(F)(F)C(O)=O>>[C:1]([N:4]1[CH2:8][C@H:7]([NH:9][S:10]([C:13]2[CH:14]=[CH:15][C:16]([O:19][CH2:20][C:21]3[C:30]4[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=4)[N:24]=[C:23]([CH3:31])[CH:22]=3)=[CH:17][CH:18]=2)(=[O:12])=[O:11])[C@H:6]([C:32]([OH:34])=[O:33])[CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 68817317HCID 68817317, compound

Product 1

HCID 68818828HCID 68818828, compound

Procedure

According to the procedure of Example 17, Step 4, the reaction of 115 mg of tert-butyl cis-1-acetyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylate with trifluoroacetic acid provided cis-1-acetyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylic acid in quantitative yield. MS: 484.1 (M+H)+

Sources & evidence

ORD record: ord-7822380f187d4a6ab9ac5beb76684a00
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

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