Trifluoroacetic acid → HCID 86607876, compound

HRID 736730Notes

Reaction equation

[CH:1]([N:3]1[CH2:7][C@H:6]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=[C:22]([CH3:30])[CH:21]=3)=[CH:14][CH:13]=2)(=[O:11])=[O:10])[C@H:5]([C:31]([O:33]C(C)(C)C)=[O:32])[CH2:4]1)=[O:2].FC(F)(F)C(O)=O>>[CH:1]([N:3]1[CH2:7][C@H:6]([NH:8][S:9]([C:12]2[CH:17]=[CH:16][C:15]([O:18][CH2:19][C:20]3[C:29]4[C:24](=[CH:25][CH:26]=[CH:27][CH:28]=4)[N:23]=[C:22]([CH3:30])[CH:21]=3)=[CH:14][CH:13]=2)(=[O:10])=[O:11])[C@H:5]([C:31]([OH:33])=[O:32])[CH2:4]1)=[O:2]

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 86607875HCID 86607875, compound

Product 1

HCID 86607876HCID 86607876, compound

Procedure

According to the procedure of Example 17, Step 4, the reaction of 168 mg of tert-butyl cis-1-formyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylate with trifluoroacetic acid provided cis-1-formyl-4-[({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]pyrrolidine-3-carboxylic acid in quantitative yield. MS: 470.1 (M+H)+

Sources & evidence

ORD record: ord-4763a89290544df994cb70df66b37473
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

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