Hydroxylamine → HCID 86607923, compound

HRID 736837Notes

Reaction equation

[CH3:1][N:2]([S:12]([C:15]1[CH:20]=[CH:19][C:18]([O:21][CH2:22][C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[C:25]([CH3:33])[CH:24]=2)=[CH:17][CH:16]=1)(=[O:14])=[O:13])[C@@H:3]1[CH2:8][CH2:7][CH2:6][CH2:5][C@H:4]1[C:9]([OH:11])=O.[NH2:34][OH:35]>>[OH:35][NH:34][C:9]([C@@H:4]1[CH2:5][CH2:6][CH2:7][CH2:8][C@H:3]1[N:2]([CH3:1])[S:12]([C:15]1[CH:16]=[CH:17][C:18]([O:21][CH2:22][C:23]2[C:32]3[C:27](=[CH:28][CH:29]=[CH:30][CH:31]=3)[N:26]=[C:25]([CH3:33])[CH:24]=2)=[CH:19][CH:20]=1)(=[O:14])=[O:13])=[O:11]

Participants

Reactant 2

HCID 787Hydroxylamine

HCID 68818979HCID 68818979, compound

Product 1

HCID 86607923HCID 86607923, compoundYield 77%

Procedure

According to the procedure of Example 10, Step 2, the reaction of 111 mg of trans-2-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohex-anecarboxylic acid with hydroxylamine provided 71 mg of trans-N-hydroxy-2-[methyl({4-[(2-methylquinolin-4-yl)methoxy]phenyl}sulfonyl)amino]cyclohexanecarboxamide in 77% yield. MS: 484.1 (M+H)+

Sources & evidence

ORD record: ord-b8b634a62aa9444688d5f06bde8f9464
Source dataset: uspto-grants-2009_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07595327B2

Reaction notes

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