Trifluoroacetic acid → HCID 57848224, compound

HRID 736914Notes

Reaction equation

HRID 736914 reaction equation
C(O)(C(F)(F)F)=O.[CH:8]1([CH2:11][N:12]2[CH2:17][CH2:16][N:15]([CH:18]3[CH2:23][CH2:22][N:21](C(OC(C)(C)C)=O)[CH2:20][CH2:19]3)[CH2:14][CH2:13]2)[CH2:10][CH2:9]1>C(Cl)Cl>[CH:8]1([CH2:11][N:12]2[CH2:13][CH2:14][N:15]([CH:18]3[CH2:23][CH2:22][NH:21][CH2:20][CH2:19]3)[CH2:16][CH2:17]2)[CH2:9][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 685791711,1-Dimethylethyl 4-[4-(cyclopropylmethyl)-1-piperazinyl]-1-piperidinecarboxylate

Product 1

HCID 57848224HCID 57848224, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

5 mL TFA were added to a solution of 1.36 g (4.2 mmol) tert. butyl 4-(4-cyclopropylmethyl-piperazin-1-yl)-piperidine-1-carboxylate in 30 mL DCM and the reaction mixture was stirred for 4 h at RT. The reaction solution was evaporated down i.vac., the residue combined with diethyl ether, the precipitate was suction filtered and dried. The product was precipitated as the tris-trifluoroacetate salt.

Workup

  1. customThe reaction solution was evaporated down i.vac
  2. filtrationfiltered
  3. customdried
  4. customThe product was precipitated as the tris-trifluoroacetate salt

Sources & evidence

ORD record
ord-acf68cf980b54d6bb55c58a8329e5e25
Source dataset
uspto-grants-2009_09
Patent number
US07595312B2

Reaction notes

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