HCID 22184582, compound → 4-Amino-3-chloro-5-(trifluoromethyl)benzaldehyde

HRID 736919Notes

Reaction equation

HRID 736919 reaction equation
[NH2:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]([CH2:12][OH:13])=[CH:4][C:3]=1[Cl:14]>[O-2].[O-2].[Mn+4].C(Cl)Cl>[NH2:1][C:2]1[C:7]([C:8]([F:9])([F:10])[F:11])=[CH:6][C:5]([CH:12]=[O:13])=[CH:4][C:3]=1[Cl:14]

Participants

4

Reactant 1

HCID 22184582HCID 22184582, compound

Product 1

HCID 130204734-Amino-3-chloro-5-(trifluoromethyl)benzaldehyde

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 6344DichloromethaneSolvent

Procedure

A mixture of 17.0 g (75.4 mmol) of (4-amino-3-chloro-5-trifluoromethyl-phenyl)-methanol, 100 g (1.15 mol) of manganese dioxide and 300 mL of DCM was stirred overnight at RT. The precipitate was suction filtered and the solution evaporated down i. vac. The desired product was obtained as a white solid.

Workup

  1. filtrationfiltered
  2. customthe solution evaporated down i

Sources & evidence

ORD record
ord-a4d420529fd54807a75a58a761b9794f
Source dataset
uspto-grants-2009_09
Patent number
US07595312B2

Reaction notes

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