Ethanol → HCID 68591454, compound

HRID 736931Notes

Reaction equation

HRID 736931 reaction equation
[NH2:1][C@H:2]([CH2:6][C:7]1[CH:12]=[C:11]([C:13]([F:16])([F:15])[F:14])[C:10]([NH2:17])=[C:9]([Cl:18])[CH:8]=1)[C:3]([OH:5])=[O:4].[CH3:19][CH2:20]O>Cl>[NH2:1][C@H:2]([CH2:6][C:7]1[CH:12]=[C:11]([C:13]([F:15])([F:16])[F:14])[C:10]([NH2:17])=[C:9]([Cl:18])[CH:8]=1)[C:3]([O:5][CH2:19][CH3:20])=[O:4]

Participants

4

Reactant 2

HCID 702EthanolHCID 68590975HCID 68590975, compound

Product 1

HCID 68591454HCID 68591454, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 3.5 g (10.97 mmol) (R)-2-amino-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-propionic acid in 100 mL EtOH and 70 mL ethanolic HCl (11.5 M) was stirred overnight at RT. The mixture was evaporated down i.vac., the residue was taken up in 150 mL water, combined with 30 mL of 15% K2CO3 solution, extracted with 150 mL EtOAc, the organic phase was separated off and dried over Na2SO4. After removal of the desiccant and solvent the desired product was obtained.

Workup

  1. customThe mixture was evaporated down i.vac
  2. extractionextracted with 150 mL EtOAc
  3. customthe organic phase was separated off
  4. dry with materialdried over Na2SO4
  5. customAfter removal of the desiccant and solvent the desired product
  6. customwas obtained

Sources & evidence

ORD record
ord-3217b716ae0b4c59bab1481664b0bcb1
Source dataset
uspto-grants-2009_09
Patent number
US07595312B2

Reaction notes

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