反应详情

A solution of 3.5 g (10.97 mmol) (R)-2-amino-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-propionic acid in 100 mL EtOH and 70 mL ethanolic HCl (11.5 M) was stirred overnight at RT. The mixture was evaporated down i.vac., the residue was taken up in 150 mL water, combined with 30 mL of 15% K2CO3 solution, extracted with 150 mL EtOAc, the organic phase was separated off and dried over Na2SO4. After removal of the desiccant and solvent the desired product was obtained.

1. customThe mixture was evaporated down i.vac
2. extractionextracted with 150 mL EtOAc
3. customthe organic phase was separated off
4. dry with materialdried over Na2SO4
5. customAfter removal of the desiccant and solvent the desired product
6. customwas obtained