Lithium hydroxide, monohydrate → HCID 68591673, compound

Participants

Reaction Steps

To a suspension of 6.0 g (10.31 mmol) ethyl (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carbonyl]-amino}-propionate in 50 mL THF was added a solution of 0.64 g (15 mmol) lithium hydroxide hydrate in 100 mL of water. A further 100 mL each of water and THF were added to this suspension, and after 5 min a solution was formed. It was stirred for 1 h at RT, the THF was eliminated i.vac., diluted with 100 mL of water and 1 M HCl was added dropwise while cooling with ice until an acidic reaction was obtained. The substance precipitated was filtered, washed with water and dried in the air.

Provenance & Evidence