反应详情

To a suspension of 6.0 g (10.31 mmol) ethyl (R)-3-(4-amino-3-chloro-5-trifluoromethyl-phenyl)-2-{[4-(2-oxo-1,2,4,5-tetrahydro-1,3-benzodiazepin-3-yl)-piperidin-1-carbonyl]-amino}-propionate in 50 mL THF was added a solution of 0.64 g (15 mmol) lithium hydroxide hydrate in 100 mL of water. A further 100 mL each of water and THF were added to this suspension, and after 5 min a solution was formed. It was stirred for 1 h at RT, the THF was eliminated i.vac., diluted with 100 mL of water and 1 M HCl was added dropwise while cooling with ice until an acidic reaction was obtained. The substance precipitated was filtered, washed with water and dried in the air.

1. customafter 5 min a solution was formed
2. additionwas added dropwise
3. temperaturewhile cooling with ice until an acidic reaction
4. customwas obtained
5. customThe substance precipitated
6. filtrationwas filtered
7. washwashed with water
8. customdried in the air