Hydrochloric Acid → HCID 57848406, compound

Participants

Reaction Steps

1.0 mL (1.00 mmol) 1 M NaOH were added to a solution of 80 mg (0.11 mmol) ethyl {4-[1-(3-(4-bromo-3-methyl-phenyl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-carbonyl]-amino}-propionyl)-piperidin-4-yl]-piperazin-1-yl}-acetate (Example 14.4) in 4 mL THF. The reaction mixture was stirred overnight at RT and the solvent was eliminated i. vac. 1 mL 1 M HCl was added to the residue and it was evaporated to dryness again. The residue was taken up in EtOH and after filtration the mother liquor was concentrated by evaporation i.vac. The residue was triturated with diisopropylether and after filtration dried in the air.

Provenance & Evidence