Hydrochloric Acid → HCID 57848406, compound

HRID 736956Notes

Reaction equation

HRID 736956 reaction equation
[OH-].[Na+].[Br:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([NH:32][C:33]([N:35]2[CH2:40][CH2:39][CH:38]([N:41]3[CH2:50][C:49]4[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=4)[NH:43][C:42]3=[O:51])[CH2:37][CH2:36]2)=[O:34])[C:12]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]([O:29]CC)=[O:28])[CH2:22][CH2:21]3)[CH2:16][CH2:15]2)=[O:13])=[CH:6][C:5]=1[CH3:52].Cl>C1COCC1>[Br:3][C:4]1[CH:9]=[CH:8][C:7]([CH2:10][CH:11]([NH:32][C:33]([N:35]2[CH2:36][CH2:37][CH:38]([N:41]3[CH2:50][C:49]4[C:44](=[CH:45][CH:46]=[CH:47][CH:48]=4)[NH:43][C:42]3=[O:51])[CH2:39][CH2:40]2)=[O:34])[C:12]([N:14]2[CH2:19][CH2:18][CH:17]([N:20]3[CH2:25][CH2:24][N:23]([CH2:26][C:27]([OH:29])=[O:28])[CH2:22][CH2:21]3)[CH2:16][CH2:15]2)=[O:13])=[CH:6][C:5]=1[CH3:52]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 57848497HCID 57848497, compound

Product 1

HCID 57848406HCID 57848406, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

1.0 mL (1.00 mmol) 1 M NaOH were added to a solution of 80 mg (0.11 mmol) ethyl {4-[1-(3-(4-bromo-3-methyl-phenyl)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-carbonyl]-amino}-propionyl)-piperidin-4-yl]-piperazin-1-yl}-acetate (Example 14.4) in 4 mL THF. The reaction mixture was stirred overnight at RT and the solvent was eliminated i. vac. 1 mL 1 M HCl was added to the residue and it was evaporated to dryness again. The residue was taken up in EtOH and after filtration the mother liquor was concentrated by evaporation i.vac. The residue was triturated with diisopropylether and after filtration dried in the air.

Workup

  1. customwas evaporated to dryness again
  2. filtrationafter filtration the mother liquor
  3. concentrationwas concentrated by evaporation i.vac
  4. customThe residue was triturated with diisopropylether
  5. filtrationafter filtration
  6. customdried in the air

Sources & evidence

ORD record
ord-e066220cfb4341708d9ca5b51fbcceca
Source dataset
uspto-grants-2009_09
Patent number
US07595312B2

Reaction notes

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