Ammonia → 5-(Aminomethyl)-3-pyridinecarbonitrile
Reaction equation
Cl[CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9].[NH3:11]>CO>[NH2:11][CH2:2][C:3]1[CH:4]=[N:5][CH:6]=[C:7]([CH:10]=1)[C:8]#[N:9]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 80 °C
Procedure
Dissolve 5-chloromethyl-nicotinonitrile (4.9 mg, 0.032 mmol) in 2.0M NH3 in MeOH (1 mL). Transfer this solution to a pressure tube. Heat the reaction solution at 80° C. for 2 h. Rotary evaporate the reaction solution (40° C.) to yield 5.1 mg of crude 5-aminomethyl-nicotinonitrile as a yellow oil. MS (m/e): 134.00 (M+1).
Workup
- customRotary evaporate the reaction solution (40° C.)
Sources & evidence
- ORD record
- ord-74cb9da3642e4a8ab7e7ac7180288e20
- Source dataset
- uspto-grants-2009_09
- Patent number
- US07595339B2
Reaction notes
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