Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 5-(Chloromethyl)pyridine-3-carbonitrile | HCID 22146711 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Aminomethyl)nicotinonitrile | HCID 20063942 | — |
Reaction Steps
Dissolve 5-chloromethyl-nicotinonitrile (4.9 mg, 0.032 mmol) in 2.0M NH3 in MeOH (1 mL). Transfer this solution to a pressure tube. Heat the reaction solution at 80° C. for 2 h. Rotary evaporate the reaction solution (40° C.) to yield 5.1 mg of crude 5-aminomethyl-nicotinonitrile as a yellow oil. MS (m/e): 134.00 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07595339B2 |
|---|
| Source dataset | uspto-grants-2009_09 |
|---|
| ORD ID | ord-74cb9da3642e4a8ab7e7ac7180288e20 |
|---|
| Source note | uspto-grants-2009_09 |
|---|
