反应详情

温度

90 °C

Ref: _Angew. Chem. Int. Ed._ **2006** , _45_ , 6523-6527 1\. To a microwave tube was added N-(5-amino-2-cyclopropylphenyl)acetamide (0.038 g, 0.20 mmol), 5-chloro-7-(oxetan-3-ylamino)pyrazolo[1,5-a]pyrimidine-3-carbonitrile (0.060 g, 0.24 mmol), Cs2CO3 (0.196 g, 0.60 mmol), Pd2dba3 (0.018 g, 0.02 mmol), and di-tert-butyl(2',4',6'-triisopropylbiphenyl-2-yl)phosphine (0.017 g, 0.04 mmol). The mixture was dissolved in DMF (0.5 mL) and sealed. The tube was de- gassed and inflated with N2. 2\. The reaction was heated at 90°C in oil-bath overnight. LCMS showed SM and byproducts and small amount of product mass. did not workup