反应详情

温度

0 °C

Dissolve 4-phenyl-azetidin-2-one (1.0 g, 4.28 mmol) in anhydrous THF (20 mL) and treat with 1.0 M solution of lithium aluminum hydride (8.57 mL, 2.0 equiv.) at room temperature. Stir for 15 h, cool to 0° C. in an ice bath and quench with 8.5 mL 1.0 M NaOH then 8.5 mL H2O. Filter resulting solution through celite with additional EtOAc, dry with MgSO4, filter and evaporate to yield a milky white oil that solidifies upon standing. Use 2-Phenyl-azetidine without further purification.

1. customquench with 8.5 mL 1.0 M NaOH
2. filtrationFilter
3. customresulting solution through celite with additional EtOAc
4. dry with materialdry with MgSO4
5. filtrationfilter
6. customevaporate
7. customto yield a milky white oil
8. customUse 2-Phenyl-azetidine without further purification