Triphenylphosphine → HCID 57849505, compound

HRID 737107Notes

Reaction equation

HRID 737107 reaction equation
[C:1]([O:5][C:6](=[O:17])[N:7]([CH2:14][CH2:15][OH:16])[CH2:8][CH:9](O)[CH:10]([CH3:12])[CH3:11])([CH3:4])([CH3:3])[CH3:2].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.CCOC(/N=N/C(OCC)=O)=O>C1(C)C=CC=CC=1>[C:1]([O:5][C:6]([N:7]1[CH2:14][CH2:15][O:16][CH:9]([CH:10]([CH3:12])[CH3:11])[CH2:8]1)=[O:17])([CH3:4])([CH3:3])[CH3:2]

Participants

5

Reactant 3

HCID 11776TriphenylphosphineHCID 5462977Diethyl azodicarboxylateHCID 57849638HCID 57849638, compound

Product 1

HCID 57849505HCID 57849505, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent2×

Procedure

The above compound could be made in the following manner: 1 eq. of (2-Hydroxy-ethyl)-(2-hydroxy-3-methyl-butyl)-carbamic acid tert-butyl ester and 1.2 eq. of triphenylphosphine could be dissolved in toluene. 1.2 eq. of diethylazodicarboxylate in toluene could be added dropwise to the resulting solution at room temperature under argon atmosphere and the mixture could be stirred overnight. The solvent could be removed in vacuo and the material purified by column chromatography.

Workup

  1. customThe solvent could be removed in vacuo
  2. customthe material purified by column chromatography

Sources & evidence

ORD record
ord-c9a8b8f54c2c44edba6e9599f0b94748
Source dataset
uspto-grants-2009_09
Patent number
US07595397B2

Reaction notes

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