反应详情

温度

80 °C

This compound could be made in the following manner: 100 mg of (3-phenyl-piperazin-1-yl)-(2′-trifluoromethyl-biphenyl-4-yl)-methanone would be dissolved in 3 mL of acetonitrile, 2 equiv. of N,N-diisopropylethylamine would be added followed by 1.1 equiv. of iodomethane. The reaction would be heated to 80° C. overnight. After cooling to room temperature, the reaction would be diluted with dichloromethane and washed with 1M aqueous sodium hydroxide solution, dried over sodium sulfate and concentrated in vacuo. The crude residue would be purified by column chromatography to afford the title compound.

1. customThe reaction
2. temperatureAfter cooling to room temperature
3. customthe reaction
4. washwashed with 1M aqueous sodium hydroxide solution
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customThe crude residue would be purified by column chromatography