反应详情

The above compound could be made the following way: 1 eq. of 2-Phenylmorpholine (Array) in dichloroethane could be combined with 1.2 eq. 4′-Bromoacetophenone (Aldrich) and stirred overnight at room temperature. 1.5 eq. borane-pyridine complex could be added and the reaction stirred for several hours. The reaction mixture could be diluted with methylene chloride and washed with water and brine. The organics could be dried over sodium sulfate and purified by column chromatography.

1. addition1.5 eq. borane-pyridine complex could be added
2. washwashed with water and brine
3. dry with materialThe organics could be dried over sodium sulfate
4. custompurified by column chromatography