反应详情

温度

70 °C

A solution of 4-(2-Amino-thiazol-4-yl)-N-cyclopropyl-benzamide (265 mg, 1 mmol), in THF (5 mL), was treated with Lawesson's reagent (0.75 eq) and heated to 70° C. overnight in a sealed vial. The reaction was cooled, filtered and the solvents removed. The resulting mixture was redissolved in 5 ml of 90% DMF, 10% water with 0.1% TFA and purified by reverse phase HPLC to give the product. MS: 275.4 (M+H+).

1. temperatureThe reaction was cooled
2. filtrationfiltered
3. customthe solvents removed
4. dissolutionThe resulting mixture was redissolved in 5 ml of 90% DMF
5. custom10% water with 0.1% TFA and purified by reverse phase HPLC
6. customto give the product