Sodium Acetate → HCID 86616441, compound

HRID 737195Notes

Reaction equation

HRID 737195 reaction equation
[CH2:1]([O:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([C:16](=O)[CH2:17]Br)=[N:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:21][C:22]([NH2:24])=[S:23].CC([O-])=O.[Na+]>CCO>[CH2:1]([O:8][C:9](=[O:20])[C:10]1[CH:15]=[CH:14][C:13]([C:16]2[N:21]=[C:22]([NH2:24])[S:23][CH:17]=2)=[N:12][CH:11]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 517045Sodium AcetateHCID 2723790ThioureaHCID 86616442HCID 86616442, compound

Product 1

HCID 86616441HCID 86616441, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 6-(2-bromo-acetyl)-nicotinic acid benzyl ester (0.16 g, 0.48 mmol), thiourea (0.0.038 g), and NaOAc (0.051 g) in EtOH (6 mL) was stirred at room temperature overnight. The mixture was concentrated in vacuo to give the crude product 6-(2-Amino-thiazol-4-yl)-nicotinic acid benzyl ester.

Workup

  1. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-6bf6a643b04c4bd78ec1ebd23b6e84b6
Source dataset
uspto-grants-2009_09
Patent number
US07595398B2

Reaction notes

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