反应详情

To a solution of R-9 (500 mg, 2.06 mmol) and R-10 (337.6 mg, 2.06 mmol) in DMF (20 mL) is added oxone (758.5 mg, 1.23 mmol) and the solution is stirred at room temperature for 1 hour. The mixture is concentrated in vacuo and the residue is diluted in CH2Cl2 and is washed with saturated aqueous NaHCO3. The organics are dried with Na2SO4, filtered and concentrated in vacuo to give R-11 (787 mg).

1. concentrationThe mixture is concentrated in vacuo
2. additionthe residue is diluted in CH2Cl2
3. washis washed with saturated aqueous NaHCO3
4. dry with materialThe organics are dried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated in vacuo