p-Toluidine → 4-Methoxy-4'-methyldiphenylamine

HRID 739162노트

반응식

HRID 739162 반응식
COc1ccc(I)cc1.Cc1ccc(N)cc1>CN(C)C(=NC(C)(C)C)N(C)C.COC(=O)c1ccno1.COc1ccc(OC)c([P](C(C)(C)C)(C(C)(C)C)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O>COc1ccc(Nc2ccc(C)cc2)cc1

참가 물질

7

반응물 2

HCID 7813p-ToluidineHCID 696764-Iodoanisole

생성물 1

HCID 114358284-Methoxy-4'-methyldiphenylamine수율 35.245%

시약·촉매·용매 4

HCID 2736892Methyl isoxazole-5-carboxylate시약HCID 35715812-tert-Butyl-1,1,3,3-tetramethylguanidine시약HCID 178492620HCID 178492620, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

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온도
60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

  1. addition기록된 절차가 없습니다

출처 및 근거

ORD 기록
ord-8c20447c69a9413eb9100921c8fa7d91
출처 데이터셋
Ahneman

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