p-Toluidine → 3-Pyridinamine, N-(4-methylphenyl)-

HRID 739815노트

반응식

HRID 739815 반응식
Brc1cccnc1.Cc1ccc(N)cc1>CCOC(=O)c1cnoc1C.CN1CCCN2CCCN=C12.COc1ccc(OC)c([P](C(C)(C)C)(C(C)(C)C)->[Pd]2(<-[NH2]c3ccccc3-c3cccc[c]32)[O]S(=O)(=O)C(F)(F)F)c1-c1c(C(C)C)cc(C(C)C)cc1C(C)C.CS(C)=O>Cc1ccc(Nc2cccnc2)cc1

참가 물질

7

반응물 2

HCID 7813p-ToluidineHCID 122863-Bromopyridine

생성물 1

HCID 6035893-Pyridinamine, N-(4-methylphenyl)-수율 45.502%

시약·촉매·용매 4

HCID 1235837-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene시약HCID 7009317Ethyl 5-methylisoxazole-4-carboxylate시약HCID 178492620HCID 178492620, 화합물촉매HCID 679Dimethyl Sulfoxide용매5회

반응 조건

온도
60 °C

실험 절차

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

후처리

  1. addition기록된 절차가 없습니다

출처 및 근거

ORD 기록
ord-adc909c9459f49cf81292c4b55b5dc87
출처 데이터셋
Ahneman

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