反应详情

温度

0 °C

To a solution of 2-t-butyl-4-bromophenol (380 g, 1.67 mol) in dichloromethane (1000 mL) was added Et3N (202 g, 2 mol) at room temperature. Methyl chloroformate (155 mL) was added dropwise to the above solution at 0° C. After addition, the mixture was stirred at 0° C. for 2 h., quenched with saturated ammonium chloride solution and diluted with water. The organic layer was separated and washed with water and brine, dried over Na2SO4, and concentrated to provide the crude methyl (2-tert-butyl-4-bromophenyl) carbonate (470 g), which was used without further purification.

1. additionAfter addition
2. customquenched with saturated ammonium chloride solution
3. additiondiluted with water
4. customThe organic layer was separated
5. washwashed with water and brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated