反应详情

To a 100 mL single-neck flask, 5.6 g (0.02 mol) (R)-N-benzyl-2-(ethoxycarbonylamino)-3-methoxypropionamide and 50 mL 31% concentrated hydrochloric acid were added, the mixture was heated and refluxed for 6-10 hr. After the reaction was completed, 30% sodium hydroxide solution was added to adjust the pH value of the system to 8-9. The reaction liquid was extracted with 50 mL×2 dichloromethane, and dried over anhydrous sodium sulfate. The product can be directly used in following synthesis without further purification.

1. temperaturethe mixture was heated
2. temperaturerefluxed for 6-10 hr
3. customThe reaction liquid
4. extractionwas extracted with 50 mL×2 dichloromethane
5. dry with materialdried over anhydrous sodium sulfate
6. customsynthesis
7. customwithout further purification