反应详情

To a solution of indoline (3.58 g, 30 mmol) in ethanol (50 mL) was added ethyl 2-methylthio-4-hydroxypyrimidine-5-carboxylate (5.35 g, 25 mmol) and the mixture was heated under reflux for 18 h. The reaction mixture was allowed to cool to room temperature and the precipitated crystals were collected by filtration. The crystals were washed several times with cold ethanol and dried to give the title compound (5.5 g, 77%) as crystals.

1. temperaturethe mixture was heated
2. temperatureunder reflux for 18 h
3. filtrationthe precipitated crystals were collected by filtration
4. washThe crystals were washed several times with cold ethanol
5. customdried