反应详情

An eggplant flask was charged with 4-fluoro-3-nitrobenzoic acid (2.51 g, 13.56 mmol), aniline (2.52 g, 27.12 mmol), and ethanol (9.5 mL), and this was heated to reflux with stirring for 16 hours. After cooling to room temperature, the mixture was poured into dilute hydrochloric acid (1 M, 50 mL), diluted with distilled water (100 mL), was left to stir as is at room temperature for 30 minutes. The precipitated crystals were filtered off, and washed successively with dilute hydrochloric acid (1 M, with approx. 3 mL 3 times), distilled water (approx. 5 mL 2 times), and with diethyl ether (approx. 3 mL). The crystals obtained were dried at reduced pressure with heating to yield the title compound (3.39 g, quant.) as a reddish-orange solid.

1. temperaturethis was heated
2. temperatureto reflux
3. waitwas left
4. stirringto stir
5. waitas is at room temperature for 30 minutes
6. filtrationThe precipitated crystals were filtered off
7. washwashed successively with dilute hydrochloric acid (1 M, with approx. 3 mL 3 times)
8. distillationdistilled water (approx. 5 mL 2 times)
9. customThe crystals obtained
10. customwere dried at reduced pressure
11. temperaturewith heating