反应详情

温度

98 °C

A 3-neck flask (200 mL) was charged with 1-fluoro-2-nitro-4-trifluoromethylbenzene (1.59 g, 7.61 mmol), 4-aminotetrahydropyran (1.00 g, 9.89 mmol), and pyridine (16 mL), and this was stirred at 98° C. for 23 hours. The yellow oil produced was allowed to cool, distilled water (approx. 20 mL) was added with stirring, and the precipitated crystals were filtered off. These were washed with distilled water and dried with heating at reduced pressure to yield the title compound (2.00 g, 90.5% yield) as yellow crystals.

1. customThe yellow oil produced
2. temperatureto cool
3. distillationdistilled water (approx. 20 mL)
4. additionwas added
5. stirringwith stirring
6. filtrationthe precipitated crystals were filtered off
7. washThese were washed with distilled water
8. customdried
9. temperaturewith heating at reduced pressure