HuagongsheHuagongshe Chemistry Print Report · For research reference only
1H-Indole-3-carbonyl chloride → Quinolizidin-2-ylmethylindole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1H-Indole-3-carbonyl chloride | HCID 12380278 | — |
| Reactant | Octahydro-2H-quinolizine-2-methanol | HCID 70077295 | — |
| Product | Quinolizidin-2-ylmethylindole-3-carboxylate | HCID 131719520 | — |
Reaction Steps
The title compound was prepared from ax-2-hydroxymethylquinolizidine (D4) and indole-3-carboxylic acid chloride using the method of Example 1. The product was purified by chromatography on neutral alumina eluting with ethyl acetate, followed by crystallisation from ether/pentane, to give the title compound (E9a) as a white solid mp 156°-157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552398 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-eea0e5d430844394884ee1af1c97ceb5 |
| Source note | uspto-grants-1996_09 |