Hydrochloric Acid → 5-(Benzothiazol-2-yl)-2-hydroxymethyl-1-phenylbenzimidazole

Participants

Reaction Steps

An eggplant flask (50 mL) equipped with a reflux condenser was charged with 5-(benzothiazol-2-yl)-1-phenyl-2-(phenylmethoxy)methylbenzimidazole (see Working Example 1-2) (0.40 g, 0.89 mmol) and dilute hydrochloric acid (6 M, 5 mL), and this was refluxed for 2 hours. When the pale yellow clear solution obtained was cooled in ice, it became a milky white suspension. The precipitated crystals were filtered off, washed successively with distilled water, and then t-butyl methyl ether, and dried under reduced pressure to yield the title compound (0.30 g, 94% yield) as a white powder.

Provenance & Evidence