反应详情

An eggplant flask (50 mL) equipped with a reflux condenser was charged with 5-(benzothiazol-2-yl)-1-phenyl-2-(phenylmethoxy)methylbenzimidazole (see Working Example 1-2) (0.40 g, 0.89 mmol) and dilute hydrochloric acid (6 M, 5 mL), and this was refluxed for 2 hours. When the pale yellow clear solution obtained was cooled in ice, it became a milky white suspension. The precipitated crystals were filtered off, washed successively with distilled water, and then t-butyl methyl ether, and dried under reduced pressure to yield the title compound (0.30 g, 94% yield) as a white powder.

1. customAn eggplant flask (50 mL) equipped with a reflux condenser
2. temperaturethis was refluxed for 2 hours
3. customWhen the pale yellow clear solution obtained
4. temperaturewas cooled in ice
5. filtrationThe precipitated crystals were filtered off
6. washwashed successively with distilled water
7. dry with materialt-butyl methyl ether, and dried under reduced pressure