HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Bromo-2-methylpropane → Quinolizidin-2-ylmethyl-1-isobutylindole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Bromo-2-methylpropane | HCID 6555 | — |
| Reactant | Quinolizidin-2-ylmethylindole-3-carboxylate | HCID 131719520 | — |
| Product | Quinolizidin-2-ylmethyl-1-isobutylindole-3-carboxylate | HCID 131719528 | — |
Reaction Steps
eq-Quinolizidin-2-ylmethylindole-3-carboxylate (E9b) was alkylated with 1-bromo-2-methylpropane using the method in Example 18. The product was chromatographed on silica gel eluting initially with ether, then with ethyl acetate, to afford the title compound (E20) as a colourless oil. This was converted to its hydrochloride salt mp 174°-175° C. (acetone/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552398 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-cde6ba34dbe54f17a57946b65f156353 |
| Source note | uspto-grants-1996_09 |