反应详情

A stirred solution of N-chlorosuccinimide (220 mg, 0.0016 mole) in chloroform (6 ml) at room temperature under nitrogen was treated with a solution of eq-quinolizidin-2-ylmethylindole-3-carboxylate (E9b) (330 mg, 0.0011 mole) in chloroform (6 ml) and stirred for 2 h. The solution was then treated with methanol (0.71 ml, 0.022 mole) and stirring continued. After 3 h a beige precipitate began to form and afar a further 1 h this was filtered off, washed with chloroform,and dried to afford the title compound (E26) as its hydrochloride salt mp 212°-213° C.

1. stirringstirring
2. waitAfter 3 h a beige precipitate began
3. customto form
4. waitafar a further 1 h
5. filtrationthis was filtered off
6. washwashed with chloroform,and
7. customdried