HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → 1-Phenyl-2-bromo-2-(4-(methylsulfonyl)phenyl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-Phenyl-2-bromo-2-(4-(methylthio)phenyl)ethanone | HCID 19426791 | — |
| Reactant | Potassium hydroxy sulfite | HCID 23707502 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 1-Phenyl-2-bromo-2-(4-(methylsulfonyl)phenyl)ethanone | HCID 15315212 | — |
Reaction Steps
To a suspension of the product of step 2 (59 g, 183 mmol) in a mixture of CH2Cl2 (300 mL), MeOH (1 L), t-BuOH (350 mL) was added a suspension of oxone (248 g, 403 mmol) in 700 mL of H2O. The mixture was stirred for 1 h. Saturated NaHCO3 was added slowly until all solid dissolved. The resulting mixture was extracted with Et2O. The ether extracts were dried (Na2SO4) and concentrated to give 39.3 g of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552422 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-ebd3301c4156428e973849d59c7cfcb3 |
| Source note | uspto-grants-1996_09 |