反应详情

温度

120 °C

To ethyl 4-hydroxy-2-(2,3-dihydro-1H-indol-1-yl)-5-pyrimidinecarboxylate (2.85 g, 10 mmol) was added phosphorus oxychloride (10 mL, 2 mmol) and the mixture was stirred at 120° C. for 15 h. The reaction mixture was concentrated under reduced pressure. The obtained residue was dissolved in ethyl acetate, washed with saturated aqueous sodium hydrogencarbonate solution (×3) and saturated brine (×1) and dried over anhydrous sodium sulfate. The solvent was concentrated under reduced pressure to give the title compound (2.9 g, 100%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. dissolutionThe obtained residue was dissolved in ethyl acetate
3. washwashed with saturated aqueous sodium hydrogencarbonate solution (×3) and saturated brine (×1)
4. dry with materialdried over anhydrous sodium sulfate
5. concentrationThe solvent was concentrated under reduced pressure