反应详情

Potassium t-butoxide (0.37 g) and 3-bromo-1-propene (0.3 ml) were added to a solution of 2-(dimethylaminomethylene)aminoimidazole (0.2 g) in DMF (3 ml) under ice-cooling. After warming to room temperature, the mixture was stirred for 30 minutes. Water was added to the reaction mixture, and the product was extracted with chloroform. The extract was dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The resulting residue was purified by column chromatography on silica gel (eluent: chloroform-methanol-ammonia water=40:1:0.1) to give 2-(dimethylaminomethylene)amino-1-(2-propenyl)imidazole (0.31 g, Yield: 80%) as a brown oil.

1. temperaturecooling
2. extractionthe product was extracted with chloroform
3. dry with materialThe extract was dried over anhydrous magnesium sulfate
4. customthe solvent was evaporated under reduced pressure
5. customThe resulting residue was purified by column chromatography on silica gel (eluent: chloroform-methanol-ammonia water=40:1:0.1)