HCID 67740613, compound → HCID 67740771, compound

HRID 741716Notes

Reaction equation

HRID 741716 reaction equation
[ClH:1].Cl.C[O:4][C:5](=[O:15])[C@H:6]([CH2:8][N:9]1[CH:13]=[CH:12][N:11]=[C:10]1[NH2:14])[NH2:7]>Cl>[ClH:1].[ClH:1].[NH2:14][C:10]1[N:9]([CH2:8][C@@H:6]([C:5]([OH:15])=[O:4])[NH2:7])[CH:13]=[CH:12][N:11]=1

Participants

3

Reactant 1

HCID 67740613HCID 67740613, compound

Product 1

HCID 67740771HCID 67740771, compoundYield 117.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Conditions

Temperature
55 °C

Procedure

3-(2-Aminoimidazol-1-yl)-L-alanine methyl ester dihydrochloride (103 mg) was dissolved in 6N hydrochloric acid (4 ml), and the mixture was stirred at 55° C. for 5 days. The solvent was evaporated under reduced pressure. Methanol was added to the residue, and the insoluble materials were filtered off. Evaporation of the solvent in the filtrate gave the title compound (57 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. additionMethanol was added to the residue
  3. filtrationthe insoluble materials were filtered off
  4. customEvaporation of the solvent in the filtrate

Sources & evidence

ORD record
ord-ba548afe8e8046469eee613158f0c304
Source dataset
uspto-grants-1996_09
Patent number
US05552427

Reaction notes

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