Hydrogen Bromide → HCID 19354001, compound

HRID 741732Notes

Reaction equation

HRID 741732 reaction equation
C[O:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1.[BrH:26]>C(O)(=O)C>[BrH:26].[OH:2][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][CH:25]=1)[CH2:6][N:7]1[C:11]2[CH:12]=[CH:13][CH:14]=[CH:15][C:10]=2[N:9]=[C:8]1[C:16]1[CH:21]=[CH:20][CH:19]=[C:18]([CH3:22])[CH:17]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 19353915HCID 19353915, compound

Product 1

HCID 19354001HCID 19354001, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

This compound was prepared by first synthesizing 1-(3-methoxybenzyl)-2-(3-methylphenyl)benzimidazole as described in Example 65, supra. With an amount of the compound of Example 65 (4.31 g, 13.12 mmol) in glacial acetic acid (50 ml) and hydrobromic acid (300 ml of a 48% w/v in acetic acid solution). This mixture was stirred for 2 hours while warming to reflux. The mixture was then stirred at reflux for about three hours.

Workup

  1. temperaturewhile warming to reflux
  2. stirringThe mixture was then stirred
  3. temperatureat reflux for about three hours

Sources & evidence

ORD record
ord-31e59c6a64ff4fdba635438443e8b9b2
Source dataset
uspto-grants-1996_09
Patent number
US05552426

Reaction notes

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