反应详情

温度

80 °C

To a solution of the sulfoxide from Step 2 (0.35 g, 1.29 mmol) in dichloroethane (2.6 mL) was added TFAA (2.6 mL). The mixture was stirred at 80° C. for 0.5 h, cooled and evaporated. The residue was dissolved in MeOH: Et3N (1:1, 5 mL). The solvent was evaporated and taken up again in MeOH/Et3N. After evaporation of the solvent and chromatography using hexane:EtOAc (70:30) 0.28 g of the title compound was obtained.

1. temperaturecooled
2. customevaporated
3. dissolutionThe residue was dissolved in MeOH: Et3N (1:1, 5 mL)
4. customThe solvent was evaporated
5. customAfter evaporation of the solvent and chromatography
6. customwas obtained