反应详情

5-(Benzoxazol-2-yl)-2-(tetrahydropyran-4-yl)aminoaniline (see Working Example 20-2) (0.20 g, 0.646 mmol) in trifluoroacetic acid (7 mL) was heated to reflux for 4.5 hours. The reaction mixture was cooled, water was added, and this was extracted with ethyl acetate. The organic layer was washed with aqueous sodium carbonate solution and water, then dried over magnesium sulfate, and concentrate. The residue was purified by silica gel column chromatography to yield the title compound (139 mg, 55.5% yield) as white crystals.

1. temperatureto reflux for 4.5 hours
2. temperatureThe reaction mixture was cooled
3. extractionthis was extracted with ethyl acetate
4. washThe organic layer was washed with aqueous sodium carbonate solution and water
5. dry with materialdried over magnesium sulfate
6. concentrationconcentrate
7. customThe residue was purified by silica gel column chromatography