Hydrogen Bromide → HCID 70195407, compound

HRID 742016Notes

Reaction equation

HRID 742016 reaction equation
[NH2:1][C:2]1[C:24]([CH3:25])=[C:23]([CH3:26])[C:5]2[O:6][C@@:7]([CH3:22])([CH2:9][N:10]3[CH2:15][CH2:14][CH:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:12][CH2:11]3)[CH2:8][C:4]=2[C:3]=1[CH3:27].[BrH:28]>CO.C(O)(=O)C>[BrH:28].[BrH:28].[NH2:1][C:2]1[C:24]([CH3:25])=[C:23]([CH3:26])[C:5]2[O:6][C@@:7]([CH3:22])([CH2:9][N:10]3[CH2:15][CH2:14][CH:13]([C:16]4[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=4)[CH2:12][CH2:11]3)[CH2:8][C:4]=2[C:3]=1[CH3:27]

Participants

5

Reactant 2

HCID 260Hydrogen BromideHCID 10785018HCID 10785018, compound

Product 1

HCID 70195407HCID 70195407, compound

Reagents, catalysts & solvents 2

HCID 176Acetic AcidSolventHCID 887MethanolSolvent

Procedure

(R)--(-)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidinomethyl )-2,3-dihydrobenzo [b]furan (860 mg) was dissolved in methanol and to the solution was added 25% hydro bromide in acetic acid solution (0.5 ml) and then concentrated. The residue was dissolved in methanol and left. The resulting crystal was collected by filtration and washed with ethanol to yield 810 mg of (R)--(-)-5-amino-2,4,6,7-tetramethyl-2-(4-phenylpiperidino-methyl)-2,3-dihydrobenzo [b]furan dihydrobromide.

Workup

  1. concentrationconcentrated
  2. dissolutionThe residue was dissolved in methanol
  3. waitleft
  4. filtrationThe resulting crystal was collected by filtration
  5. washwashed with ethanol

Sources & evidence

ORD record
ord-69cb85343a254857ae9a4714920c2c62
Source dataset
uspto-grants-1996_09
Patent number
US05552552

Reaction notes

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