Chlorine → Methyl 2-(chloromethyl)-phenylglyoxylate

HRID 742188Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 742188
[CH3:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[C:9]([O:11][CH3:12])=[O:10].[Cl:14]Cl>ClC(Cl)(Cl)Cl>[Cl:14][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=[O:13])[C:9]([O:11][CH3:12])=[O:10]

Komponenten

4

Edukt 2

HCID 24526ChlorineHCID 3768392Methyl (2-methylphenyl)(oxo)acetate

Produkt 1

HCID 14697243Methyl 2-(chloromethyl)-phenylglyoxylateAusbeute 35 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 5943Carbon TetrachlorideLösungsmittel

Versuchsvorschrift

100 g (0.56 mole) of methyl 2-methylphenylglyoxylate in 600 ml of tetrachloromethane are initially taken. The mixture is then refluxed while being exposed to a 300 W Hg vapor lamp, and 28 g (0.39 mole) of chlorine gas are passed in during this procedure. After a conversion of about 50% (determined by thin-layer chromatography), the reaction is terminated and the mixture is evaporated down. The residue is then subjected to fractional distillation. 29 g of product were obtained as an oil.

Aufarbeitung

  1. temperatureThe mixture is then refluxed
  2. customAfter a conversion of about 50% (determined by thin-layer chromatography), the reaction is terminated
  3. customthe mixture is evaporated down
  4. distillationThe residue is then subjected to fractional distillation

Quellen und Nachweise

ORD-Eintrag
ord-b078b43321954c5dbf1f20ce9bcbd3c2
Quelldatensatz
uspto-grants-1996_09
Patentnummer
US05554578

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