Triethylamine → HCID 18968211, compound

HRID 742229Notes

Reaction equation

HRID 742229 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([N:9]=[C:10]=[S:11])[CH:5]=[CH:6][C:7]=1[CH3:8].Cl.C([O:15][C:16](=O)[CH2:17][NH:18][CH3:19])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]([N:9]2[C:16](=[O:15])[CH2:17][N:18]([CH3:19])[C:10]2=[S:11])[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1405053-Chloro-4-methylphenyl isothiocyanateHCID 171173Ethyl N-methylaminoacetate hydrochloride

Product 1

HCID 18968211HCID 18968211, compoundYield 57.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 1 using 18.3 g of 3-chloro-4-methylphenyl-isothiocyanate, 15.3 g of sarcosine ethyl ester hydrochloride, 25 g of triethyl amine, and 300 mL of chloroform. Crystallization from ethyl acetate afforded the title compound (14.5 g) as an off-white solid, m.p. 178°-180° C. Anal. Calcd. for C11H11Cl N2O S: C, 51.87; H, 4.35; N,11.00. Found: C, 1.89; H, 4.20; N, 10.95. Mass spectrum (+FAB, [M+H]+) m/z 255/257.

Workup

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from ethyl acetate

Sources & evidence

ORD record
ord-e81ae652dda448528084933f195add34
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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