Triethylamine → HCID 85701472, compound

HRID 742236Notes

Reaction equation

HRID 742236 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]=[C:10]=[S:11])[CH3:2].Cl.C([O:15][C:16](=O)[CH2:17][NH:18][CH3:19])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[N:9]1[C:16](=[O:15])[CH2:17][N:18]([CH3:19])[C:10]1=[S:11])[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 171173Ethyl N-methylaminoacetate hydrochlorideHCID 27962132-Ethylphenyl isothiocyanate

Product 1

HCID 85701472HCID 85701472, compoundYield 87.4%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 1 using 16.3 g of 2-ethylphenyl-isothiocyanate, 15.3 g of sarcosine ethyl ester hydrochloride, 20.2 g of triethyl amine, and 300 mL of chloroform. The title compound (20.4 g) was obtained as an off-white solid, m.p. 135°-137° C. Anal. Calcd. for C12H14N2O S: C, 61.51; H, 6.02; N,11.96. Found: C, 61.11; H, 5.92; N, 11.71. Mass spectrum (El, M.+) m/z 234.

Workup

  1. customThe title compound was prepared by the procedure

Sources & evidence

ORD record
ord-8c9dec8772f44059ba34d62f0421b16d
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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