Triethylamine → HCID 11737434, compound

HRID 742237Notes

Reaction equation

HRID 742237 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]=[S:11].Cl.C([O:15][C:16](=O)[CH2:17][NH:18][CH3:19])C.C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:16](=[O:15])[CH2:17][N:18]([CH3:19])[C:10]1=[S:11]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1232391,3-Dichloro-2-isothiocyanatobenzeneHCID 171173Ethyl N-methylaminoacetate hydrochloride

Product 1

HCID 11737434HCID 11737434, compoundYield 87.8%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 1 using 14.28 g of 2,6-dichlorophenyl-isothiocyanate, 10.75 g of sarcosine ethyl ester hydrochloride, 14.5 g of triethyl amine, and 200 mL of chloroform. Crystallization from diethyl ether afforded the title compound (16.9 g) as a light peach solid, m.p. 207°-209° C. Anal. Calcd. for C10H8C12N2O S: C, 43.65; H, 2.93; N, 10.18. Found: C, 43.57; H, 2.61; N, 10.14. Mass spectrum (El, M.+) m/z 274.

Workup

  1. customThe title compound was prepared by the procedure
  2. customCrystallization from diethyl ether

Sources & evidence

ORD record
ord-3e7d38a7d8d1437cae79959f7a71ddfe
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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