Triethylamine → HCID 11415027, compound

HRID 742239Notes

Reaction equation

HRID 742239 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]=[C:10]=[S:11].[CH2:12]([NH:14][CH2:15][C:16](O)=[O:17])[CH3:13].C(N(CC)CC)C>C(Cl)(Cl)Cl>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([Cl:8])[C:3]=1[N:9]1[C:16](=[O:17])[CH2:15][N:14]([CH2:12][CH3:13])[C:10]1=[S:11]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 1232391,3-Dichloro-2-isothiocyanatobenzeneHCID 316542N-Ethylglycine

Product 1

HCID 11415027HCID 11415027, compoundYield 45%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 16 using 10.2 g of 2,6-dichlorophenyl-isothiocyanate, 7.4 g of N-ethyl glycine, 10 g of triethyl amine, and 250 mL of chloroform. Purification was achieved through crystallization from ethanol. The title compound (6.5 g) was obtained as a tan solid, m.p. 170°-172° C. Anal. Calcd. for. C11H10C12N2O S: C, 45.69; H, 3.48; N, 9.69. Found: C, 45.53; H, 3.19; N, 9.62. Mass spectrum (El, M.+) m/z 288/290/292.

Workup

  1. customThe title compound was prepared by the procedure
  2. customPurification
  3. customwas achieved through crystallization from ethanol

Sources & evidence

ORD record
ord-0897c523d209484eb270b380382d3d9a
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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