Triethylamine → HCID 11207147, compound

HRID 742240Notes

Reaction equation

HRID 742240 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]=[C:9]=[S:10])=[CH:4][CH:3]=1.[CH2:11]([NH:13][CH2:14][C:15](O)=[O:16])[CH3:12].C(N(CC)CC)C>C(Cl)(Cl)Cl>[CH2:11]([N:13]1[CH2:14][C:15](=[O:16])[N:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[C:9]1=[S:10])[CH3:12]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 152414-Fluorophenyl isothiocyanateHCID 316542N-Ethylglycine

Product 1

HCID 11207147HCID 11207147, compoundYield 55.5%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

The title compound was prepared by the procedure described in Example 16 using 7.65 g of 4-fluorophenyl-isothiocyanate, 9.32 g of N-ethyl glycine, 10 g of triethyl amine, and 250 mL of chloroform. Purification was achieved through crystallization from ethanol. The title compound (6.6 g) was obtained as a pink solid, m.p. 149°-151° C. Anal. Calcd. for. C11H11F N2O S: C, 55.45; H, 4.65; N, 11.76. Found: C, 55.31; H, 4.51; N, 10.82. Mass spectrum (EI, M.+) m/z 238.

Workup

  1. customThe title compound was prepared by the procedure
  2. customPurification
  3. customwas achieved through crystallization from ethanol

Sources & evidence

ORD record
ord-835b6c83cd934335a30079f919c14639
Source dataset
uspto-grants-1996_09
Patent number
US05554607

Reaction notes

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