Hydrochloric Acid → HCID 22905844, compound

HRID 742295Notes

Reaction equation

HRID 742295 reaction equation
[F:1][C:2]([F:37])([F:36])[C:3]1[CH:4]=[C:5]([CH2:13][CH2:14][C:15](=[O:35])[CH:16]([NH:27]C(OC(C)(C)C)=O)[CH2:17][C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[NH:20][CH:19]=2)[CH:6]=[C:7]([C:9]([F:12])([F:11])[F:10])[CH:8]=1.[ClH:38]>>[ClH:38].[NH2:27][CH:16]([C:15](=[O:35])[CH2:14][CH2:13][C:5]1[CH:6]=[C:7]([C:9]([F:10])([F:12])[F:11])[CH:8]=[C:3]([C:2]([F:1])([F:36])[F:37])[CH:4]=1)[CH2:17][C:18]1[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[NH:20][CH:19]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 22905843HCID 22905843, compound

Product 1

HCID 22905844HCID 22905844, compound

Procedure

The product of part (d) was treated with ethereal hydrogen chloride for one hour. The precipitated white solid was filtered and dried, mp=84°-86° C.; found: C,54.40; H, 4.25; N, 6.10; C21H18F6N2O. HCl requires C, 54.26; H, 4.12; N, 6.03%.

Workup

  1. filtrationThe precipitated white solid was filtered
  2. customdried

Sources & evidence

ORD record
ord-09c86d5959a14dd5a1d37bd0031d5eea
Source dataset
uspto-grants-1996_09
Patent number
US05554627

Reaction notes

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