反应详情

To a methanol (5 mL) solution of 2-(2-n-butylaminoanilin-5-yl)benzoxazole (see Working Example 74-2) (300 mg, 1.07 mmol) was added methyl acetimidate hydrochloride (175 mg, 1.60 mmol), and this was heated to reflux for 3 hours. After the reaction was complete, saturated aqueous sodium hydrogen carbonate solution was added, and this was extracted with chloroform. After the organic layer obtained was dried over anhydrous sodium sulfate, it was filtered and concentrated. The crystals obtained were purified by silica gel column chromatography to yield the title compound (293 mg, 90% yield) as white crystals.

1. temperaturethis was heated
2. temperatureto reflux for 3 hours
3. extractionthis was extracted with chloroform
4. customAfter the organic layer obtained
5. dry with materialwas dried over anhydrous sodium sulfate, it
6. filtrationwas filtered
7. concentrationconcentrated
8. customThe crystals obtained
9. customwere purified by silica gel column chromatography